“Three-parent baby” technique and the Mexican legal system
Técnica “bebé de tres padres” y el sistema jurídico mexicano
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Abstract
The three-parent baby technique is a form of assisted reproduction that involves genetic manipulation to prevent mitochondrial diseases. The purpose of the article is to comprehensively analyze the ethical, legal, social, medical, and scientific considerations related to the three-parent baby technique and provide a global overview of the feasibility, risks, and benefits of its implementation. The methodology used is based on a thorough review of scientific literature and critical analysis of different aspects related to the three-parent baby technique. Clinical studies, ethical research, and legal regulations are examined, and social and cultural implications are considered. The results show that the three-parent baby technique raises significant ethical considerations regarding informed consent, genetic manipulation, and genetic identity. Additionally, legal challenges are identified in terms of the rights and responsibilities of biological parents and the need for specific regulation. Furthermore, social and cultural concerns, equity in access, and the perception of this technique in different communities are highlighted. Regarding medical and scientific aspects, the importance of evaluating effectiveness, safety, and potential risks associated with the technique is emphasized, as well as the appropriate selection of donors and medical follow-up. By addressing these aspects appropriately, the benefits of this technique can be maximized, and the rights and well-being of all parties involved can be protected.
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Allier, A., Moreau, L., Charcosset, A., Teyssedre, S., y Lehermeier, C. (2018). Usefulness Criterion and Post-Selection Parental Contributions in Multi-Parental Crosses: Application to Polygenic Trait Introgression. G3: Genes|Genomes|Genetics, 9, 1469 - 1479. https://doi.org/10.1534/g3.119.400129
Bartal, M., Sibai, B., Bart, Y., Shina, A., Mazaki‐Tovi, S., Eisen, I., Hendler, I., Baum, M., y Schiff, E. (2018). The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications. American Journal of Perinatology, 36, 205 - 211. https://doi.org/10.1055/s-0038-1667029
Bauer, T. (2022). A Systematic Review of Qualitative Studies Investigating Motives and Experiences of Recipients of Anonymous Gamete Donation. Frontiers in Sociology, 7. https://doi.org/10.3389/fsoc.2022.746847
Blank, D., Blank, D., Badurdeen, S., Badurdeen, S., Kamlin, C., Jacobs, S., Thió, M., Dawson, J., Kane, S., Kane, S., Dennis, A., Dennis, A., Polglase, G., Hooper, S., y Davis, P. (2018). Baby-directed umbilical cord clamping: A feasibility study. Resuscitation, 131, 1-7. https://doi.org/10.1016/j.resuscitation.2018.07.020.
Blázquez, A., Garcia, D., Vassena, R., Figueras, F., y Rodríguez, A. (2018). Risk of preeclampsia in pregnancies resulting from double gamete donation and from oocyte donation alone. Pregnancy hypertension, 13, 133-137. https://doi.org/10.1016/j.preghy.2018.06.010
Casasempere-Satorres, A., y Vercher-Ferrándiz, M. L. (2020). Bibliographic documentary analysis. Getting the most out of the literature review in qualitative research. New Trends in Qualitative Research, 4, 247-257. https://doi.org/10.36367/ntqr.4.2020.247-257
Childress, J., y Childress, M. (2020). What Does the Evolution From Informed Consent to Shared Decision Making Teach Us About Authority in Health Care? AMA journal of ethics, 22 5, E423-429. https://doi.org/10.1001/amajethics.2020.423
Clayton, E., Evans, B., Hazel, J., y Rothstein, M. (2019). The law of genetic privacy: applications, implications, and limitations. Journal of Law and the Biosciences, 6, 1 - 36. https://doi.org/10.1093/jlb/lsz007
Creswell, J. W. (2019). Research Design. Qualitative, Quantitative and Mixed Method Approaches (SAGE, Ed. 4 ed.).
Dimond, R., y Stephens, N. (2018). Three persons, three genetic contributors, three parents: Mitochondrial donation, genetic parenting and the immutable grammar of the ‘three x x’. Health:, 22, 240 - 258. https://doi.org/10.1177/1363459316689380
Eilertsen, E., Jami, E., McAdams, T., Hannigan, L., Havdahl, A., Magnus, P., Evans, D., y Ystrom, E. (2020). Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA. Behavior Genetics, 51, 154 - 161. https://doi.org/10.1007/s10519-020-10036-6
Faddy, M., Gosden, M., y Gosden, R. (2018). A demographic projection of the contribution of assisted reproductive technologies to world population growth. Reproductive biomedicine online, 36 4, 455-458. https://doi.org/10.1016/j.rbmo.2018.01.006
Gobierno de México (2015). Ley General de Salud. Dirección General de Promoción de la Salud. Secretaría de Salud. https://www.gob.mx/salud/articulos/ley-de-salud
Gómez, C. A. (2022). Ingreso, permanencia y estrategias para el fomento de los Semilleros de Investigación en una IES de Colombia. Región Científica, 1(1), 20226. https://doi.org/10.58763/rc20226
Gullo, G., Scaglione, M., Cucinella, G., Perino, A., Chiantera, V., D’Anna, R., Laganà, A., y Buzzaccarini, G. (2022). Impact of assisted reproduction techniques on the neuro-psycho-motor outcome of newborns: a critical appraisal. Journal of Obstetrics and Gynaecology, 42, 2583 - 2587. https://doi.org/10.1080/01443615.2022.2109953
Huang, C., Wu, H., Zhou, W., Huang, Z., Luo, X., Tang, Y., Liu, Q., Fan, L., Nie, H., y Zhu, W. (2022). Genetic testing of sperm donors at a human sperm bank in China. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.942447
Johnson, L., Duenas, D., y Wilfond, B. (2021). Conjoined Consent: Informed Consent When Donor and Recipient Are Both Research Participants. The American Journal of Bioethics, 21, 106 - 107. https://doi.org/10.1080/15265161.2021.1891343
Kater-Kuipers, A., Beaufort, I., Galjaard, R., y Bunnik, E. (2020). Rethinking counselling in prenatal screening: An ethical analysis of informed consent in the context of non‐invasive prenatal testing (NIPT). Bioethics, 34, 671 - 678. https://doi.org/10.1111/bioe.12760
Kool, E., Bos, A., Graaf, R., Fauser, B., y Bredenoord, A. (2018). Ethics of oocyte banking for third-party assisted reproduction: a systematic review. Human Reproduction Update, 24, 615–635. https://doi.org/10.1093/humupd/dmy016
Macpherson, I., Roqué, M., y Segarra, I. (2019). Ethical Challenges of Germline Genetic Enhancement. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00767
Mihelic, M., Morawska, A., y Filus, A. (2018). Preparing parents for parenthood: protocol for a randomized controlled trial of a preventative parenting intervention for expectant parents. BMC Pregnancy and Childbirth, 18. https://doi.org/10.1186/s12884-018-1939-2
O'Brien, K., Robson, K., Bracht, M., Cruz, M., Lui, K., Alvaro, R., Silva, O., Monterrosa, L., Narvey, M., Ng, E., Soraisham, A., Ye, X., Mirea, L., Tarnow-Mordi, W., y Lee, S. (2018). Effectiveness of Family Integrated Care in neonatal intensive care units on infant and parent outcomes: a multicentre, multinational, cluster-randomised controlled trial. The Lancet. Child & adolescent health, 2 4, 245-254. https://doi.org/10.1016/S2352-4642(18)30039-7
Pant, S., Elias, M., Woolfall, K., Morales, M., Lincy, B., Jahan, I., Sumanasena, S., Ramji, S., Shankaran, S., y Thayyil, S. (2021). Parental and professional perceptions of informed consent and participation in a time-critical neonatal trial: a mixed-methods study in India, Sri Lanka and Bangladesh. BMJ Global Health, 6. https://doi.org/10.1136/bmjgh-2021-005757
Pennings, G. (2019). Genetic databases and the future of donor anonymity. Human reproduction, 34 5, 786-790. https://doi.org/10.1093/humrep/dez029
Pennings, G. (2020). Decisional authority of gamete donors over embryos created with their gametes. Journal of Assisted Reproduction and Genetics, 37, 281-286. https://doi.org/10.1007/s10815-019-01678-5
Pinto, N., Simões, R., Amorim, A., y Conde-Sousa, E. (2019). Optimizing the information increase through the addition of relatives and genetic markers in identification and kinship cases. Forensic science international. Genetics, 40, 210-218. https://doi.org/10.1016/j.fsigen.2019.02.019
Pompei, M., y Pompei, F. (2018). Overcoming bioethical, legal, and hereditary barriers to mitochondrial replacement therapy in the USA. Journal of Assisted Reproduction and Genetics, 36, 383 - 393. https://doi.org/10.1007/s10815-018-1370-7
Priego, R., Martínez, G. Rodríguez, M. A. (2021). La publicidad digital y el desafío de la saturación publicitaria para el empresario. FACE: Revista De La Facultad De Ciencias Económicas Y Empresariales, 21(2), 46-51. https://doi.org/10.24054/01204211.v2.n2.2021.4651
Savulescu, J., y Singer, P. (2019). An ethical pathway for gene editing. Bioethics, 33 2, 221-222. https://doi.org/10.1111/bioe.12570
Simon, K., y Farr, R. (2020). Identity-based socialization and adopted children’s outcomes in lesbian, gay, and heterosexual parent families. Applied Developmental Science, 26, 155 - 175. https://doi.org/10.1080/10888691.2020.1748030
Slade, A., Holland, M., Ordway, M., Carlson, E., Jeon, S., Close, N., Mayes, L., y Sadler, L. (2020). Minding the Baby®: Enhancing parental reflective functioning and infant attachment in an attachment-based, interdisciplinary home visiting program. Development and Psychopathology, 32, 123 - 137. https://doi.org/10.1017/S0954579418001463
Soares, C., Tkachenko, N., Fernandes, E., Barreiro, M., Abreu, M., Reis, C., Soares, G., Fortuna, A., y Soares, A. (2022). Genetic counseling and carrier screening in candidates for gamete donation at a Portuguese center. JBRA Assisted Reproduction, 27, 180 - 184. https://doi.org/10.5935/1518-0557.20220012
Tamanza, G., Facchin, F., Francini, F., Ravani, S., Gennari, M., y Mannino, G. (2019). “Doubly Mother”: Heterologous Artificial Insemination Between Biological and Social Parenthood: A Single Case Study. World Futures, 75, 480 - 501. https://doi.org/10.1080/02604027.2019.1654769
Taylor, J. (2019). Social Autonomy and Family-Based Informed Consent. The Journal of medicine and philosophy, 44 5, 621-639. https://doi.org/10.1093/JMP/JHZ020
Xia, D., Zhang, C., Lip, V., Harris, M., y Shen, Y. (2018). Trio-R: a script for assessing maternity and paternity in trio studies performed on Agilent chromosomal microarrays. BMC Medical Informatics and Decision Making, 18. https://doi.org/10.1186/s12911-018-0684-9
Zegers‐Hochschild, F., Schwarze, J., Crosby, J., Musri, C., y Urbina, M. (2018). Assisted reproductive techniques in Latin America: the Latin American Registry, 2015. Reproductive biomedicine online, 37 6, 685-692. https://doi.org/10.1016/j.rbmo.2018.08.026
Zong, L., Liu, P., Zhou, L., Wei, D., Ding, L., y Qin, Y. (2020). Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer. Reproductive Biology and Endocrinology: RB&E, 18. https://doi.org/10.1186/s12958-020-00601-3
